Database : HANSEN Search on : TESTE TUBERCULINICO [Subject descriptor] References found : 14 [refine] Displaying: 1 .. 14   in format [Detailed]

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Id: 17318 Author: Black, Gillian F; Weir, Rosemari E; Chaguluka, Steven D; Warndorff, David; Crampin, Amelia C; Mwaungulu, Lorren; Sichali, Lifted; Floyd, Sian; Bliss, Lyn; Jarman, Elizabeth; Docovan, Linda; Andersen, Peter; Britton, Warwick; Hewinson, Glyn; Huygen, Kris; Paulsen, Jean; Sing, Mahavir; Prestidge, Ross; Fine, Paul E. M; Dockrell, Hazel M Title: Gama interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-Mycobacterium bovis BCG-vaccinated Malawian young adults ..- Source: s.l; s.n; 2003. 10 p. graf. Abstract: We have previously shown that young adults living in a rural area of northern Malawi showed greater gamma interferon (IFN-gamma) responses to purified protein derivatives (PPD) prepared from environmental mycobacteria than to PPD from Mycobacterium tuberculosis. In order to define the mycobacterial species to which individuals living in a rural African population have been exposed and sensitized, we tested T-cell recognition of recombinant and purified antigens from M. tuberculosis (38 kDa, MPT64, and ESAT-6), M. bovis (MPB70), M. bovis BCG (Ag85), and M. leprae (65 kDa, 35 kDa, and 18 kDa) in >600 non-M. bovis BCG-vaccinated young adults in the Karonga District of northern Malawi. IFN-gamma was measured by enzyme-linked immunosorbent assay (ELISA) in day 6 supernatants of diluted whole-blood cultures. The recombinant M. leprae 35-kDa and 18-kDa and purified native M. bovis BCG Ag85 antigens induced the highest percentages of responders, though both leprosy and bovine tuberculosis are now rare in this population. The M. tuberculosis antigens ESAT-6 and MPT64 and the M. bovis antigen MPB70 induced the lowest percentages of responders. One of the subjects subsequently developed extrapulmonary tuberculosis; this individual had a 15-mm-diameter reaction to the Mantoux test and responded to M. tuberculosis PPD, Ag85, MPT64, and ESAT-6 but not to any of the leprosy antigens. We conclude that in this rural African population, exposure to M. tuberculosis or M. bovis is much less frequent than exposure to environmental mycobacteria such as M. avium, which have antigens homologous to the M. leprae 35-kDa and 18-kDa antigens. M. tuberculosis ESAT-6 showed the strongest association with the size of the Mantoux skin test induration, suggesting that among the three M. tuberculosis antigens tested it provided the best indication of exposure to, or infection with, M. tuberculosis. (AU). Descriptors: Antígenos de Bactérias/*IM Vacina BCG/*IM Interferon Tipo II/*BI Hanseníase/EP Malauí/EP Mycobacterium/GE/*IM Mycobacterium bovis/IM Mycobacterium leprae/IM Mycobacterium tuberculosis/IM Proteínas Recombinantes de Fusão/IM Especificidade de Espécies Linfócitos T/IM Teste Tuberculínico Tuberculose/IM Vacinação Limits: Adolescente Adulto Criança Estudo Comparativo Feminino Humano Masculino População Rural Location: BR191.1; 00224/s

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Id: 15815 Author: Convit, Jacinto. Title: Lepromin and tuberculin tests in Venezuelan leprosy foci, induction of lepromin reactivity by BCG vaccination. Source: Int. J. Lepr;22(3):303-310, July-Sept. 1954. tab, graf. Abstract: The reactions to tuberculin and lepromin were studied in 8,353 inhabitants of leprosy foci in rural areas in Venezuela. Of this general group, a total of 1,356 (16.2 per cent) proved to be negative to the Mitsuda, test, while 5,205 (62.5 per cent) were Mantoux negative, In the group of Mitsuda-positive persons 44.8 per cent were also Mantoux positive, while in the Mitsuda-negative group only 3 per cent were Mantoux positive. In the Mantoux-positive group 99.5 per cent were Mitsuda-positive, while in the Mantoux-negative group 74.4 per cent were Mitsuda-positive. Considering that 16.2 per cent of the persons examined were found to be without protection against leprosy in the first tests, and taking into account that almost all lepromatous and indeterminate cases come from the lepromin negatives, which form the endemic matrix of the disease, there can be no doubt but that BCG vaccination will be an effective prophylaxis, at least in rural areas, when it can reduce the percentage of Mitsuda negative from 16.2 to 1.3 per cent. (AU). Descriptors: HANSENIASE HANSENIASE/diag HANSENIASE/terap TESTE TUBERCULINICO/clas HANSENIASE/prev Electronic Medium: http://www.ilsl.br Location: BR191.1

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Id: 13666 Author: Bala, Lakshmi; Anand, Sukumar; Sinha, Sudhir Title: Enhancement of human T cell response to a peptide epitope of 38kDa antigen of Mycobacterium tuberculosis by liposomes ..- Source: s.l; s.n; 2002. 9 p. graf. Abstract: Diagnosis of tuberculosis a problem, specially in the regions harboring an abundance of both pathogenic and non-pathogenic mycobacteria. This study was undertaken to assess in such a situation the predictive value of proliferative T cell response to a peptide epitope ('38G') of the 38 kDa membrane protein of Mycobacterium tuberculosis. 3[H]-thymidine incorporation assays were done with peripheral blood mononuclear cells of tuberculoid leprosy and pulmonary tuberculosis patients. The donors were also classified as PPD responders (Stimulation Index, SI> 3) or non-responders (SI < or = 3) on the basis of their T cell response to the 'Purified Protein Derivative (PPD)' of M. tuberculosis. 38G peptide was used in either free or liposome-associated form prepared by the technique of 'Dehydration-rehydration Vesicles' (Kirby and Gregoriadis, 1984). While free peptide failed to induce a positive response in study subjects, its liposomal form was T cell stimulatory and distinguished, to certain extent, between PPD responders (corresponding SI > 3 in 54 per cent subjects) and non-responders (SI > 3 in 29 per cent subjects). However, it did not differentiate between leprosy and tuberculosis. The study supports use of liposomes as adjuvant vehicles for antigenic peptides designed to activate human T cells. (AU). Descriptors: ANTIGENOS DE BACTERIAS/admin ANTIGENOS DE BACTERIAS/quim ANTIGENOS DE BACTERIAS/genet HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/imunol EPITOPOS/admin EPITOPOS/quim EPITOPOS/genet DIAGNOSTICO DIFERENCIAL MYCOBACTERIUM TUBERCULOSIS/quim MYCOBACTERIUM TUBERCULOSIS/genet MYCOBACTERIUM TUBERCULOSIS/imunol DADOS DE SEQUÊNCIA MOLECULAR SEQUÊNCIA DE AMINOACIDOS LINFOCITOS T/imunol TESTE TUBERCULINICO TUBERCULOSE PULMONAR/diag TUBERCULOSE PULMONAR/imunol TRANSFORMACAO LINFOCITICA - LIPOSSOMOS  PESO MOLECULAR Limits: ESTUDO COMPARATIVO HUMANO IN VITRO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09061/s

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Id: 13317 Author: Stanley, Susan J; Howland, C; Stone, Mary M; Sutherland, I Title: BCG vaccination of children against leprosy in Uganda: final results ..- Source: s.l; s.n; oct. 1981. 16 p. tab. Abstract: A total of 19200 children, all contacts or realtives of known leprosy patients, anda all free of visible leprosy lesions, were included in a controlled trial of BCG vaccination against leprosy in Uganda between 1960 and 1964.(AU). Descriptors: VACINA BCG SEGUIMENTOS HANSENIASE/epidemiol HANSENIASE/prev TESTE TUBERCULINICO UGANDA VACINACAO - FATORES DE TEMPO Limits: HUMANO PRÉ-ESCOLAR CRIANÇA ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01183/s

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Id: 12277 Author: Fine, P. E. M; Floyd, S; Stanford, J. L; Nkhosa, P; Kasunga, A; Chaguluka, S; Warndorff, D. K; Jenkins, P. A; Yates, M; Ponnighaus, J. M Title: Environmental mycobacteria in northern Malawi: implications for the epidemiology of tuberculosis and leprosy ..- Source: s.l; s.n; 2001. 9 p. tab, graf. Descriptors: ADOLESCENCIA DISTRIBUIÇAO POR IDADE ANTIGENOS DE BACTÉRIAS CRIANÇA EXPOSIÇAO AMBIENTAL SEGUIMENTOS INCIDENCIA HANSENIASE HANSENIASE HANSENIASE MALAUI MYCOBACTERIUM MYCOBACTERIUM MYCOBACTERIUM MYCOBACTERIUM VIGILANCIA DA POPULAÇAO QUESTIONARIOS FATORES DE RISCO SAUDE RURAL DISTRIBUIÇAO POR SEXO PELE MICROBIOLOGIA DO SOLO TESTE TUBERCULINICO TUBERCULOSE TUBERCULOSE TUBERCULOSE MICROBIOLOGIA DA AGUA Location: BR191.1; 08629/s

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Id: 11888 Author: Siddiqui, M. Ruby; Moreira, Andre L; Negesse, Yohannes; Taye, Genet A; Hanekom, Willem A; Haslett, Patrick A; Britton, Swen; Kaplan, Gilla Title: Local nerve damage in leprosy does not lead to an impaired cellular immune response or decreased wound healing in the skin ..- Source: s.l; s.n; 2002. 6 p. ilus, tab. Descriptors: HANSENIASE HANSENIASE HANSENIASE ANTIGENOS CD1 ANTIGENOS CD13 ANTIGENOS CD18 BIOPSIA HIPERSENSIBILIDADE TARDIA IMUNOHISTOQUIMICA MYCOBACTERIUM LEPRAE NEURITE NEURITE NEURITE TESTE TUBERCULINICO CICATRIZAÇAO DE FERIDAS Location: BR191.1; 08577/s

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Id: 11489 Author: Fine, P. E. M; Floyd, S; Stanford, J. L; Nkhosa, P; Kasunga, A; Chaguluka, S; Warndorff, D. K; Jenkins, P. A; Yates, M; Ponnighaus, J. M Title: Environmental mycobacteria in northern Malawi: implications for the epidemiology of tuberculosis and leprosy ..- Source: s.l; s.n; 2001. 9 p. tab, graf. Descriptors: HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM MYCOBACTERIUM MYCOBACTERIUM MYCOBACTERIUM INCIDENCIA MALAUI VIGILANCIA DA POPULAÇAO FATORES DE RISCO SAUDE RURAL DISTRIBUIÇAO POR SEXO PELE MICROBIOLOGIA DO SOLO TESTE TUBERCULINICO TUBERCULOSE TUBERCULOSE TUBERCULOSE MICROBIOLOGIA DA AGUA ANTIGENOS DE BACTÉRIAS Location: BR191.1; 08359/s

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Id: 11013 Author: Bottasso, Oscar; Merlin, Victor; Cannon, Leslie; Cannon, Helen; Ingledew, Nicholas; Keni, Manjusha; Hartopp, Richard; Stanford, Cynthia; Stanford, John Title: Studies of vaccination of persons in close contact with leprosy patients in Argentina ..- Source: s.l; s.n; 1998. 6 p. tab. Descriptors: HANSENIASE HANSENIASE MYCOBACTERIUM MYCOBACTERIUM BOVIS PREVALENCIA TESTE TUBERCULINICO VACINAÇAO Limits: ADULTO CRIANCA HUMANO Location: BR191.1; 07289/s

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Id: 10325 Author: Rafi, Abdolnasser; Feval, Francois Title: PCR to detect mycobacterium tuberculosis DNA in sputum samples from treated leprosy patients with putative tuberculosis ..- Source: s.l; s.n; 1995. 5 p. tab. Descriptors: FATORES ETARIOS SEQUENCIA DE BASES ESTUDOS DE CASOS E CONTROLES DNA BACTERIANO INCIDENCIA IRA (GEOGRAFICO) HANSENIASE DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM TUBERCULOSIS MYCOBACTERIUM TUBERCULOSIS REAÇAO EM CADEIA POR POLIMERASE SENSIBILIDADE E ESPECIFICIDADE ESCARRO TESTE TUBERCULINICO TUBERCULOSE TUBERCULOSE TUBERCULOSE Location: BR191.1; 07175/s

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Id: 9331 Author: Barnes, Peter F; Grisso, Cara L; Abrams, John S; Brand, Hamid; Rea, Thomas H; Modlin, Robert L Title: yS T lymphocytes in human tuberculosis ..- Source: Chicago; s.n; 1992. 7 p. tab, graf. Descriptors: LINHAGEM CELULAR CITOCINAS HANSENIASE CONTAGEM DE LEUCOCITOS TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM TUBERCULOSIS LINFOCITOS T TESTE TUBERCULINICO TUBERCULOSE MILIAR TUBERCULOSE PLEURAL TUBERCULOSE PULMONAR Location: BR191.1; 06471/s

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Id: 9305 Author: Pazin Filho, Antonio; Bueno, Claudia Dizioli Franco; Pinheiro, Sandra de Azevedo; Ruffino Netto, Antonio Title: Estudos de intervencao sobre vacinacao BCG em hanseniase: uma analise comparativa Trial studies about BCG vaccination against leprosy: a comparative analysis- Source: Ribeirao Preto; s.n; 1993. 6 p. tab. Descriptors: VACINA BCG ESTUDOS DE INTERVENÇAO UGANDA NOVA GUINÉ SEGUIMENTOS MÉTODO DUPLO-CEGO MÉTODO SIMPLES-CEGO AMOSTRAGEM ESTRATIFICADA TESTE TUBERCULINICO HANSENIASE HANSENIASE HANSENIASE MIANMA LACTENTE PRÉ-ESCOLAR ADOLESCENCIA RECÉM-NASCIDO Location: BR191.1; 06214/s

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Id: 7209 Author: Fine, P. E. M; Gruer, P. J. K; Maine, N; Ponnighaus, J. M; Rees, R. J. W; Stanford, J. L Title: Failure of Mycobacterium leprae soluble antigens to suppress delayed-type hypersensivity reaction to tuberculin ..- Source: s.l; s.n; 1989. 4 p. graf. Descriptors: HANSENIASE HANSENIASE TESTE TUBERCULINICO Location: BR191.1; 05535/s

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Id: 3841 Author: Mendes, Ernesto; Raphael, Açucena; Mota, Norma G. S; Mendes, Nelson F Title: Cell-mediated immunity in leprosy and transfer of delayed hypersensivity reactions ..- Source: s.l; s.n; 1974. 7 p. tab. Descriptors: HANSENIASE ANTIBIOTICOS ANTIMICOTICOS ANTIGENOS HIPERSENSIBILIDADE TARDIA IMUNIDADE CELULAR IMUNIZAÇAO IMUNIZAÇAO PASSIVA ANTIGENO DE MITSUDA LINFOCITOS NITROBENZENOS TESTES CUTANEOS TRICOFITINA TESTE TUBERCULINICO Location: BR191.1; 02681/s

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Id: 3800 Author: Myrvang, B; Godal, T; Ridley, D. S; Fröland, S. S; Song, Y. K Title: Immune responsiveness to Mycobacterium leprae and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy ..- Source: s.l; s.n; 1973. 13 p. graf. Descriptors: MYCOBACTERIUM LEPRAE INIBIÇAO DE MIGRAÇAO CELULAR HANSENIASE HANSENIASE HANSENIASE LEUCOCITOS LEUCOCITOS TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM BOVIS PELE TESTES CUTANEOS TIMIDINA TRITIO TESTE TUBERCULINICO Location: BR191.1; 02640/s

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